Vrdyanistoi moisture concentration reaches its peak after 30 min. Pilocarpine is associated in many tissues of the eye. Its half-life period of the media eye is 1.5 – 2.5 hours. Pilocarpine appears unchanged in the intraocular fluid. The combination of it with timolol, which reduces the formation of aqueous humor, slows the rate of excretion of pilocarpine.
Pilocarpine is rapidly hydrolyzed to inactive forms in plasma and liver. The half-life of less than 0.5 hours.
Timolol quickly penetrate through the cornea into the aqueous humor of the anterior chamber. About 80% of timolol applied topically penetrates into the systemic circulation. The maximum concentration arimidex bodybuilding is determined in plasma after about 1 hour after the instillation of the eye drops. The half-life is 2-5 hours.Metabolized mainly in the liver. Write mainly by the kidneys.
glaucoma or elevated intraocular pressure when necessary combination of timolol and pilocarpine:
– Open-and-closure glaucoma;
– secondary glaucoma;
– increased intraocular pressure after ophthalmic surgery.
– Anterior uveitis;
– sinus bradycardia;
– atrioventricular block degree II-III;
– decompensated heart failure;
– cardiogenic shock;
– chronic obstructive pulmonary disease;
– Children up to age 18 years (due to lack of data on efficacy and safety of the drug in children and adolescents up to 18 years);
– hypersensitivity to any component of the drug;
– the state immediately after the eye surgeries arimidex bodybuilding and other eye diseases in which the contraction of the pupil is not desirable..
In heart failure, cerebrovascular disorders, diabetes, hypoglycemia, retinal detachment, in patients with myopia, thyrotoxicosis, and prior to surgery under general anesthesia.
Pregnancy and lactation
Eye drops can be used during pregnancy and lactation unless the expected therapeutic effect for the mother justifies the potential risk to the fetus or child.
Dosage and administration
The usual dosage – 1 drop in the affected eye 2 times a day. In some patients, the steady decline of intraocular pressure caused by drug Fotil, achieved only a few weeks, so the evaluation of therapy should include measurement of intraocular pressure after approximately 4 weeks after starting treatment. If the patient’s intraocular pressure is elevated in the treatment of eye drops Fotil®, it is recommended to continue treatment with eye drops Fotil® fort Po 1 drop 2 times a day.
On the part of the eye:
– Blurred vision,
– eye irritation;
– quickly passing a burning sensation and pain in the eye;
– increased lacrimation,
– “dry eye” syndrome
– dermatitis century;
– redness of the conjunctiva;
– a spasm of the ciliary muscle and induced myopia;
– reduced visual acuity at lighting is poor (due to miosis)
-reduction corneal sensitivity;
– punctate keratitis;
– allergic blepharoconjunctivitis.
Several cases of retinal detachment, or stiffness of the iris cyst formation in the iris of the eye have been reported in connection with the use of miotics. With arimidex bodybuilding prolonged use of pilocarpine observed reversible clouding of the lens.
Nausea, diarrhea, sweating, excessive salivation and decreased blood pressure, exacerbation of asthma, heart failure, bradycardia and arrhythmia, and Supraorbital temporal headaches, skin rash, urticaria.
Timolol penetrates the blood-brain barrier and has effects on the central nervous system.
All patients with heart failure, it can cause an asthenic syndrome, nausea, dizziness, anxiety, hallucinations, headache and depression.
Very seldom – nasal congestion, ptosis and diplopia.