The main sign of overdose with subcutaneous or intravenous administration is bleeding. It is necessary to monitor the number of platelets and other blood coagulation parameters. Minor bleeding do not require special care, it is usually sufficient to reduce or delay the subsequent dosewhat is arimidex used for. Treatment The use of protamine sulfate is only necessary in severe cases. Protamine sulfate has a strong neutralizing action with respect to anticoagulant effects of heparin, but some activity can be restored. 0.6 ml of protamine sulfate neutralizes about nadroparin . The dosage of protamine sulfate calculated from the time elapsed after the administration of heparin, with a possible reduction of the dose of antidote.
Interactions with other drugs
The development of hyperkalemia may depend on the simultaneous presence of several risk factors. Medications that cause hyperkalemia: potassium salts, potassium-sparing diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, non-steroidal anti-inflammatory agents, heparins (low molecular weight or unfractionated), cyclosporin and tacrolimus, trimethoprim. The risk of hyperkalemia is increased with a combination of the above means .
Combined use with drugs affecting hemostasis, such as acetylsalicylic acid, nonsteroidal antiinflammatory antagonists, fibrinolytics and dextran leads to mutual reinforcement effect. Furthermore, it should be taken into account: platelet aggregation inhibitors : abciximab, antiplatelet acetylsalicylic acid doses (50-300 mg) in cardiac and neurological indications, beraprost, clopidogrel, eptifibatide, iloprost, ticlopidine, tirofiban, increases the risk of bleeding.Fraksiparin should be used with caution in patients receiving oral anticoagulants, systemic glucocorticoids and dextran. In the appointment of oral anticoagulants in patients receiving Fraksiparin, its application should be continued until the stabilization indicator prothrombin time to a desired value.
Particular attention should be paid to the specific instructions for use for each drug belonging to the class of low molecular weight heparins. because Vwhat is arimidex used forunits can be used in them (IU or mg). As a consequence, it is inadmissible Fraksiparina alternation with other long-term treatment . It is also necessary to pay attention to what kind of drug is used or Fraksiparin Fraksiparin Forte becausethis affects the dosing regimen. Graded syringes intended for adjustment of the dosage depending on the patient’s body weight.
Fraksiparin not intended for intramuscular administration.
In the treatment Fraksiparinom be conducted clinical monitoring measuring platelet number. Thrombocytopenia
Since heparin is possible thrombocytopenia (heparin-induced thrombocytopenia) during the entire treatment Fraksiparinom need to monitor platelet counts.
it was reported about rare cases of thrombocytopenia, occasionally severe, which may be associated with arterial or venous thrombosis, it is important to take into account in the following cases:
- with thrombocytopenia;
- significant reduction in platelet level (30 – 50% compared with normal values);
- when the negative dynamics from thrombosis, about which the patient is receiving treatment.
In these cases, treatment what is arimidex used phentermine for should be discontinued.
These effects immunoallergic nature and are usually noted between the 5 th and 21 th day of treatment, but may occur earlier if the patient has heparin-induced thrombocytopenia in history.
In the presence of heparin-induced thrombocytopenia history (compared to normal or low molecular weight heparin), treatment can be administered if necessary. However, in this situation, showing severe clinical monitoring and at least daily measurement of the number of platelets. In the event of thrombocytopenia, should be stopped immediately.