The most common symptoms caused by an overdose of parasympathomimetic drugs and beta-blockers: bradycardia, decreased blood pressure, bronchospasm and acute cardiac insufficiency.
Treatment is mainly symptomatic. Atropine may be used as an antidote to pilocarpine. Isoprenaline can be administered intravenously to correct bradycardia or bronchospasm, dobutamine to treat hypotension.
Interaction with other medicinal products and other forms of interaction
Drugs that violate deposit catecholamines what is arimidex (reserpine) contribute to the development of arterial hypotension (including orthostatic), bradycardia, and dizziness.
Concomitant use of beta-blockers and blockers “slow” calcium channels systemic action results in the strengthening of their pharmacological effect and increases the risk of cardiac conduction disturbances, and hypotension.
CYP2D6 inhibitors such as quinidine and cimetidine, may increase the concentration of timolol in plasma.
Eye drops Fotil should not be used concomitantly with other eye drops containing beta-blockers.
Using other eye drops should be discontinued before treatment started preparations Fotil: previous glaucoma agent should be abolished, and eye drops Fotil therapy should be started the following day.
Evaluation of the effectiveness of actions should be carried out 4 weeks after initiation of treatment with regular monitoring of intraocular pressure.
Further treatment should also be carried out what is arimidex under regular control of intraocular pressure.
Fotil® eye drops contain a preservative benzalkonium chloride and should not be used while wearing contact lenses. Before using the product, remove contact lenses and re-install them no earlier than after 15 minutes.
Miotic effect may cause transient loss of vision (myopia feeling), so the period of treatment must be careful when driving or operating any complex equipment that requires high concentration and speed of psychomotor reactions.
Timolol, which is part of the drug may mask symptoms of hypoglycemia in patients with diabetes or symptoms of hyperthyroidism.
In the case of the upcoming surgery under general anesthesia, it is necessary to cancel the drug 48 hours before surgery, as enhances the action of neuromuscular what is arimidex blocking agents and general anesthetics